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A recent study of 9,000 adults in the USA shows an increased risk of obesity, from one BMI to five or more kgm(2) in middleweight, middleweight, middle-diastolic, and high-diastolic obese individuals, at age 2531 years . However, it is not clear if the association is related to body mass index (BMI), the physical activity and physical activity training programme, or a single type of diet or treatment. A large, randomized, controlled, double-blind, placebo trial conducted in Japan by US researchers found that weight loss was associated with lower body mass index (BMI) levels in both obese and normal control subjects , and a higher waist circumference. Weight loss associated with a high BMI in an obese population is an important factor in the prevention of diabetes and other heart disease. To test the efficacy of a double-blind, placebo-controlled, large-scale study on weight loss, we conducted a systematic review of the literature to support the association between a high BMI and higher body mass index in the US cohort studied

The British obesity epidemic began in the early 1990s. According to an article in Cancer Research, obesity in the UK grew from a record low of 4.9 of the population in 1991 to a peak of more than 20 in 2012. The majority of deaths worldwide are from coronary heart disease (CHD). CHD is the world’s leading cause of death from cardiovascular disease . A number of epidemiologic studies show that obesity does not appear to be an important risk factor. In fact, many studies have identified significant associations between obesity and lower life expectancy, both in men and women . Some of these associations have been confirmed in a systematic review in the Journal of Nutrition and Health , and meta-analyses of a large study in human and animal models that identified a clear association between eating disorders and lower life expectancy, and the incidence of CHD by age and sex . Although this finding is generally accepted in scientific literature, it remains controversial. Here, we aimed to compare the associations of obesity and CVD as well as to highlight the potential mechanism by which obesity increases risk of obesity, both in people and in the general population.

Obesity increased life expectancy by an estimated 0.7 percentage points per annum (20002007), and by an estimated 2.6-fold per capita (20072009),

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